How to Prevent Muscle Loss on GLP-1 Receptor Agonists.

How to prevent muscle loss on GLP-1 receptor agonists, such as Tirzepatide, Zepbound, Mounjaro, and Ozempic.

1. Increase Protein Intake: Aim for 1.2-2.2 grams per pound of body weight daily.

2. Prioritize Strength Training: Engage in resistance training (at least 4 times per week) to stimulate muscle perseveration.

3. Ensure Sufficient Calories: Avoid excess calorie deficits to prevent unnecessary muscle breakdown.

4. Monitor Body Composition: Track lean mass with DEXA scans or bioelectrical impedance analysis (BIA) rather than just focusing on weight.
   At the very least invest in a home scale that measures weight, body fat, body water, and muscle density. We recommend this CVS Body Analysis Scale.

5. Consider Creatine Supplementation: Creatine has been shown to help maintain muscle mass and strength.

Tyler Handcock MD